The pronunciation is consistent between American and British English, focusing on the initial syllable with a long "A" sound.
The name "Azotus" comes from the Greek rendition of the original Semitic name "Ashdod." During various periods of history, including when the region was under the influence of Hellenistic culture following the conquests of Alexander the Great, many Semitic names were adapted into Greek forms, which often involved changes to fit Greek phonetic and morphological patterns. The transformation of "Ashdod" into "Azotus" is an example of this type of cultural and linguistic adaptation.